Medical assistants can increase medical practice efficiency, patient satisfaction, and patient care quality, which can in turn, reduce malpractice liability risk. On the other hand, medical assistants can increase the risk that their supervising physicians and employers will be brought into a malpractice lawsuit. The case studies in this article are derived from professional liability closed claims. The strategies that follow each case present a multi-modal risk reduction approach that includes using tools to define and contain medical assistant duties; providing education on scope of service for medical assistants, supervising clinicians and physicians, and office managers; and reassessing medical assistant job duties and expertise as they expand and develop.